AUTHOR=Brindo da Cruz Isabele Camargo , Velosa Ana Paula Pereira , Carrasco Solange , dos Santos Filho Antonio , Tomaz de Miranda Jurandir , Pompeu Eduardo , Fernandes Tiago Lazzaretti , Bueno Daniela Franco , Fanelli Camila , Goldenstein-Schainberg Cláudia , Fabro Alexandre Todorovic , Fuller Ricardo , Silva Pedro Leme , Capelozzi Vera Luiza , Teodoro Walcy Rosolia TITLE=Post-Adipose-Derived Stem Cells (ADSC) Stimulated by Collagen Type V (Col V) Mitigate the Progression of Osteoarthritic Rabbit Articular Cartilage JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.606890 DOI=10.3389/fcell.2021.606890 ISSN=2296-634X ABSTRACT=
Collagen is essential for cartilage adhesion and formation. In the present study, histology, immunofluorescence, morphometry, and qRT-PCR suggested that adipose-derived stem cells (ADSCs) stimulated by type V collagen (Col V) induce a significant increase of type II collagen (Col II) in the degenerative area of surgical-induced osteoarthritic rabbit articular cartilage (OA).