AUTHOR=Karisma Vega Widya , Wu Wei , Lei Mingxing , Liu Huawen , Nisar Muhammad Farrukh , Lloyd Matthew D. , Pourzand Charareh , Zhong Julia Li TITLE=UVA-Triggered Drug Release and Photo-Protection of Skin JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.598717 DOI=10.3389/fcell.2021.598717 ISSN=2296-634X ABSTRACT=

Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a “switch on- switch off” procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures via photo-isomerization, photo-cleavage, photo-crosslinking, and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection.