This article is a correction to:
eIF3a Regulation of NHEJ Repair Protein Synthesis and Cellular Response to Ionizing Radiation
Rima Tumia1†Chao J. Wang1†Tianhan Dong1Shijie Ma2Jenny Beebe1
Juan Chen1Zizheng Dong2Jing-Yuan Liu3
Jian-Ting Zhang1,2*- 1Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States
- 2Department of Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States
- 3Department of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States
A Corrigendum on
eIF3a Regulation of NHEJ Repair Protein Synthesis and Cellular Response to Ionizing Radiation
by Tumia, R., Wang, C. J., Dong, T., Ma, S., Beebe, J., Chen, J., et al. (2020). Front. Cell Dev. Biol. 8:753. doi: 10.3389/fcell.2020.00753
In the original article, there was a mistake in Figure 1A and Figure 3A as published. Wrong images for the Western blot of H1299 cells in Figure 1A and for the comet assay of the control un-irradiated H1299 cells in Figure 3A were accidently used for publication. The corrected Figures 1 and 3 appear below.
FIGURE 1
Figure 1. Effect of eukaryotic initiation factor (eIF)3a expression on the cellular response to ionizing radiation (IR). Western blot analyses (A) and colony formation assay following IR treatment (B) of H1299 cells with transient eIF3a knockdown and NIH3T3 cells with stable eIF3a overexpression compared with their respective control cells. Actin was used as a loading control. Panel (C) shows a summary of eIF3a effects on cellular sensitivity to IR treatments. Relative resistance factor (RRF) was derived by dividing the IC50 of the test cells by that of their control cells (n = 3, **P < 0.01).
FIGURE 3
Figure 3. Role of eukaryotic initiation factor (eIF)3a in non-homologous end joining (NHEJ) repair of ionizing radiation (IR)-induced double-strand breaks (DSBs). (A,B) Comet assay was used to determine eIF3a effects on the level of DSBs induced by IR in H1299 cells with transient eIF3a knockdown (A) and NIH3T3 cells with stable eIF3a overexpression (B) compared with their respective control cells. The histograms show the summary of quantitative analysis of Olive tail moment in these cells. (C,D) Host cell reactivation assays using reporter constructs were performed using H1299 cells with eIF3a knockdown (C) and NIH3T3 cells with eIF3a stable overexpression (D) compared with their respective control cells (n = 3; **P < 0.01).
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Keywords: eukaryotic initiation factor 3a (eIF3a), DNA repair, radiation, resistance, mRNA translation, protein synthesis, gamma-H2A histone family member X (γ-H2AX)
Citation: Tumia R, Wang CJ, Dong T, Ma S, Beebe J, Chen J, Dong Z, Liu J-Y and Zhang J-T (2021) Corrigendum: eIF3a Regulation of NHEJ Repair Protein Synthesis and Cellular Response to Ionizing Radiation. Front. Cell Dev. Biol. 8:629218. doi: 10.3389/fcell.2020.629218
Received: 13 November 2020; Accepted: 15 December 2020;
Published: 07 January 2021.
Edited and reviewed by: Inna N. Lavrik, University Hospital Magdeburg, Germany
Copyright © 2021 Tumia, Wang, Dong, Ma, Beebe, Chen, Dong, Liu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jian-Ting Zhang, jianting.zhang@utoledo.edu
†These authors have contributed equally to this work