AUTHOR=Tang Zonghao , Zhang Zhenghong , Lin Qingqiang , Xu Renfeng , Chen Jiajie , Wang Yuhua , Zhang Yan , Tang Yedong , Shi Congjian , Liu Yiping , Yang Hongqin , Wang Zhengchao TITLE=HIF-1α/BNIP3-Mediated Autophagy Contributes to the Luteinization of Granulosa Cells During the Formation of Corpus Luteum JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=8 YEAR=2021 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.619924 DOI=10.3389/fcell.2020.619924 ISSN=2296-634X ABSTRACT=
During the luteinization after ovulation in mammalian ovary, the containing cells undergo an energy consuming function re-determination process to differentiate into luteal cells under avascular environment. Previous evidences have delineated the contribution of autophagy to the cell differentiation and the catabolic homeostasis in various types of mammalian cells, whereas few interest had been focused on the involvement of autophagy in the luteinization of granulosa cells during the formation of early corpus luteum. Herein, the present study investigated that expression and contribution of autophagy during granulosa cell luteinization and early luteal development through