AUTHOR=Vogel Carl-Wilhelm 

TITLE=The Role of Complement in Myocardial Infarction Reperfusion Injury: An Underappreciated Therapeutic Target

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.606407

DOI=10.3389/fcell.2020.606407

ISSN=2296-634X

ABSTRACT=<p>This article reviews the pathogenetic role of the complement system in myocardial infarction reperfusion injury. The complement activation pathways involved in myocardial tissue injury are identified, as are the complement-derived effector molecules. The results of past anti-complement therapies are reviewed; as the more recent therapeutic concept of complement depletion with humanized CVF described.</p>