AUTHOR=Chen Kaixuan , Jiao Yurui , Liu Ling , Huang Mei , He Chen , He Wenzhen , Hou Jing , Yang Mi , Luo Xianghang , Li Changjun 

TITLE=Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.598263

DOI=10.3389/fcell.2020.598263

ISSN=2296-634X

ABSTRACT=<p>The mammalian skeleton is a metabolically active organ that continuously undergoes bone remodeling, a process of tightly coupled bone resorption and formation throughout life. Recent studies have expanded our knowledge about the interactions between cells within bone marrow in bone remodeling. Macrophages resident in bone (BMMs) can regulate bone metabolism via secreting numbers of cytokines and exosomes. This review summarizes the current understanding of factors, exosomes, and hormones that involved in the communications between BMMs and other bone cells including mensenchymal stem cells, osteoblasts, osteocytes, and so on. We also discuss the role of BMMs and potential therapeutic approaches targeting BMMs in bone remodeling related diseases such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteosarcoma.</p>