AUTHOR=Beldi Ghada , Bahiraii Sheyda , Lezin Chloé , Nouri Barkestani Mahsa , Abdelgawad Mohamed Essameldin , Uzan Georges , Naserian Sina TITLE=TNFR2 Is a Crucial Hub Controlling Mesenchymal Stem Cell Biological and Functional Properties JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=8 YEAR=2020 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.596831 DOI=10.3389/fcell.2020.596831 ISSN=2296-634X ABSTRACT=
Mesenchymal stem cells (MSCs) have drawn lots of attention as gold standard stem cells in fundamental and clinical researches during the last 20 years. Due to their tissue and vascular repair capacities, MSCs have been used to treat a variety of degenerative disorders. Moreover, MSCs are able to modulate immune cells’ functions, particularly T cells while inducing regulatory T cells (iTregs). MSCs are very sensitive to inflammatory signals. Their biological functions could remarkably vary after exposure to different pro-inflammatory cytokines, notably TNFα. In this article, we have explored the importance of TNFR2 expression in a series of MSCs’ biological and functional properties. Thus, MSCs from wild-type (WT) and TNFR2 knockout (TNFR2 KO) mice were isolated and underwent several