AUTHOR=Liu Guoqing , Zhao Hongyu , Meng Hu , Xing Yongqiang , Yang Hui , Lin Hao 

TITLE=Deform-nu: A DNA Deformation Energy-Based Predictor for Nucleosome Positioning

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.596341

DOI=10.3389/fcell.2020.596341

ISSN=2296-634X

ABSTRACT=<p>The structure and function of chromatin can be regulated through positioning patterns of nucleosomes. DNA-based processes are regulated via nucleosomes. Therefore, it is significant to determine nucleosome positions in DNA-based processes. A deformation energy model was proposed to predict nucleosome positions in our previous study. A free web server based on the model (<ext-link ext-link-type="uri" xlink:href="http://lin-group.cn/server/deform-nu/" xmlns:xlink="http://www.w3.org/1999/xlink">http://lin-group.cn/server/deform-nu/</ext-link>) was firstly established to estimate the occupancy and rotational positioning of nucleosomes in the study. Then, the performance of the model was verified by several examples. The results indicated that nucleosome positioning relied on the physical properties of DNA, such as deformation energy.</p>