AUTHOR=Chen Xiaona , He Yanhong , Fu Wenjun , Sahebkar Amirhossein , Tan Yuhui , Xu Suowen , Li Hong 

TITLE=Histone Deacetylases (HDACs) and Atherosclerosis: A Mechanistic and Pharmacological Review

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.581015

DOI=10.3389/fcell.2020.581015

ISSN=2296-634X

ABSTRACT=<p>Atherosclerosis (AS), the most common underlying pathology for coronary artery disease, is a chronic inflammatory, proliferative disease in large- and medium-sized arteries. The vascular endothelium is important for maintaining vascular health. Endothelial dysfunction is a critical early event leading to AS, which is a major risk factor for stroke and myocardial infarction. Accumulating evidence has suggested the critical roles of histone deacetylases (HDACs) in regulating vascular cell homeostasis and AS. The purpose of this review is to present an updated view on the roles of HDACs (Class I, Class II, Class IV) and HDAC inhibitors in vascular dysfunction and AS. We also elaborate on the novel therapeutic targets and agents in atherosclerotic cardiovascular diseases.</p>