AUTHOR=Chen Yu-Wen , Li Shiao-Wen , Lin Chia-Der , Huang Mei-Zi , Lin Hwai-Jeng , Chin Chia-Yin , Lai Yi-Ru , Chiu Cheng-Hsun , Yang Chia-Yu , Lai Chih-Ho TITLE=Fine Particulate Matter Exposure Alters Pulmonary Microbiota Composition and Aggravates Pneumococcus-Induced Lung Pathogenesis JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=Volume 8 - 2020 YEAR=2020 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.570484 DOI=10.3389/fcell.2020.570484 ISSN=2296-634X ABSTRACT=
Exposure to fine particulate matter (PM) with aerodynamic diameter ≤2.5 μm (PM2.5) is closely correlated with respiratory diseases. Microbiota plays a key role in maintaining body homeostasis including regulation of host immune status and metabolism. As reported recently, PM2.5 exposure causes microbiota dysbiosis and thus promotes disease progression. However, whether PM2.5 alters pulmonary microbiota distribution and aggravates bacteria-induced pathogenesis remains unknown. In this study, we used mouse experimental models of PM2.5 exposure combined with