AUTHOR=Brockmann Kathrin 

TITLE=GBA-Associated Synucleinopathies: Prime Candidates for Alpha-Synuclein Targeting Compounds

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.562522

DOI=10.3389/fcell.2020.562522

ISSN=2296-634X

ABSTRACT=<p>With disease-modifying compounds targeting alpha-synuclein available in clinical trials, patient stratification according to alpha-synuclein-specific enrichment strategies is a much-needed prerequisite. Such a scenario will be exemplified for <italic>GBA</italic>, one major genetic risk factor that is specifically associated with the alpha-synucleinopathies: Parkinson’s disease and dementia with Lewy bodies.</p>