AUTHOR=Ying Zhenguang , Yang Jing , Li Wei , Wang Xia , Zhu Zeyao , Jiang Weipeng , Li Chunman , Sha Ou TITLE=Astrin: A Key Player in Mitosis and Cancer JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=8 YEAR=2020 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.00866 DOI=10.3389/fcell.2020.00866 ISSN=2296-634X ABSTRACT=

Astrin, which is a spindle-associated protein, was found to be closely related to mitotic spindle formation and maintenance. It interacts with other spindle-related proteins to play a key role in maintaining the attachment of the kinetochore-microtubule and integrity of centrosomes and promoting the centriole duplication. In addition, Astrin was quite recently found to be abnormally highly expressed in a variety of cancers. Astrin promotes the development of cancer by participating in various molecular pathways and is considered as a potential prognostic and survival predictor.