AUTHOR=Maffioli Elisa , Galli Alessandra , Nonnis Simona , Marku Algerta , Negri Armando , Piazzoni Claudio , Milani Paolo , Lenardi Cristina , Perego Carla , Tedeschi Gabriella TITLE=Proteomic Analysis Reveals a Mitochondrial Remodeling of βTC3 Cells in Response to Nanotopography JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=8 YEAR=2020 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.00508 DOI=10.3389/fcell.2020.00508 ISSN=2296-634X ABSTRACT=
Recently, using cluster-assembled zirconia substrates with tailored roughness produced by supersonic cluster beam deposition, we demonstrated that β cells can sense nanoscale features of the substrate and can translate these stimuli into a mechanotransductive pathway capable of preserveing β-cell differentiation and function