AUTHOR=Zhang Li , Haddouti El-Mustapha , Welle Kristian , Burger Christof , Wirtz Dieter C. , Schildberg Frank A. , Kabir Koroush 

TITLE=The Effects of Biomaterial Implant Wear Debris on Osteoblasts

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.00352

DOI=10.3389/fcell.2020.00352

ISSN=2296-634X

ABSTRACT=<p>Aseptic loosening subsequent to periprosthetic osteolysis is the leading cause for the revision of arthroplasty failure. The biological response of macrophages to wear debris has been well established, however, the equilibrium of bone remodeling is not only dictated by osteoclastic bone resorption but also by osteoblast-mediated bone formation. Increasing evidence shows that wear debris significantly impair osteoblastic physiology and subsequent bone formation. In the present review, we update the current state of knowledge regarding the effect of biomaterial implant wear debris on osteoblasts. The interaction of osteoblasts with osteoclasts and macrophages under wear debris challenge, and potential treatment options targeting osteoblasts are also presented.</p>