AUTHOR=Morel Etienne 

TITLE=Endoplasmic Reticulum Membrane and Contact Site Dynamics in Autophagy Regulation and Stress Response

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.00343

DOI=10.3389/fcell.2020.00343

ISSN=2296-634X

ABSTRACT=<p>Autophagy mobilizes a variety of intracellular endomembranes to ensure a proper stress response and the maintenance of cellular homeostasis. While the process of <italic>de novo</italic> biogenesis of pre-autophagic structures is not yet fully characterized, the role of the endoplasmic reticulum (ER) appears to be crucial in early steps of autophagic process. Here, I review and discuss various aspects of ER and ER-driven membrane contact site requirements and effects on mammalian organelles and endomembrane biogenesis, in particular during the early steps of autophagy-related membrane dynamics.</p>