AUTHOR=Yoest Jennifer M. , Shirai Cara Lunn , Duncavage Eric J. 

TITLE=Sequencing-Based Measurable Residual Disease Testing in Acute Myeloid Leukemia

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.00249

DOI=10.3389/fcell.2020.00249

ISSN=2296-634X

ABSTRACT=<p>Next generation sequencing (NGS) methods have allowed for unprecedented genomic characterization of acute myeloid leukemia (AML) over the last several years. Further advances in NGS-based methods including error correction using unique molecular identifiers (UMIs) have more recently enabled the use of NGS-based measurable residual disease (MRD) detection. This review focuses on the use of NGS-based MRD detection in AML, including basic methodologies and clinical applications.</p>