AUTHOR=Tu Yingfeng , Zhao Lin , Billadeau Daniel D. , Jia Da 

TITLE=Endosome-to-TGN Trafficking: Organelle-Vesicle and Organelle-Organelle Interactions

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.00163

DOI=10.3389/fcell.2020.00163

ISSN=2296-634X

ABSTRACT=<p>Retrograde transport from endosomes to the <italic>trans</italic>-Golgi network (TGN) diverts proteins and lipids away from lysosomal degradation. It is essential for maintaining cellular homeostasis and signaling. In recent years, significant advancements have been made in understanding this classical pathway, revealing new insights into multiple steps of vesicular trafficking as well as critical roles of ER-endosome contacts for endosomal trafficking. In this review, we summarize up-to-date knowledge about this trafficking pathway, in particular, mechanisms of cargo recognition at endosomes and vesicle tethering at the TGN, and contributions of ER-endosome contacts.</p>