AUTHOR=Mashkaryan Violeta , Siddiqui Tohid , Popova Stanislava , Cosacak Mehmet Ilyas , Bhattarai Prabesh , Brandt Kerstin , Govindarajan Nambirajan , Petzold Andreas , Reinhardt Susanne , Dahl Andreas , Lefort Roger , Kizil Caghan TITLE=Type 1 Interleukin-4 Signaling Obliterates Mouse Astroglia in vivo but Not in vitro JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=8 YEAR=2020 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.00114 DOI=10.3389/fcell.2020.00114 ISSN=2296-634X ABSTRACT=
Recent findings suggest that reduced neurogenesis could be one of the underlying reasons for the exacerbated neuropathology in humans, thus restoring the neural stem cell proliferation and neurogenesis could help to circumvent some pathological aspects of Alzheimer’s disease. We recently identified Interleukin-4/STAT6 signaling as a neuron–glia crosstalk mechanism that enables glial proliferation and neurogenesis in adult zebrafish brain and 3D cultures of human astroglia, which manifest neurogenic properties. In this study, by using single cell sequencing in the APP/PS1dE9 mouse model of AD, we found that IL4 receptor (