AUTHOR=Hu Ping , Barker Thomas H. 

TITLE=Thy-1 in Integrin Mediated Mechanotransduction

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=7

YEAR=2019

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2019.00022

DOI=10.3389/fcell.2019.00022

ISSN=2296-634X

ABSTRACT=<p>The glycosylphosphatidylinositol (GPI) anchored glycoprotein Thy-1 has been prevalently expressed on the surface of various cell types. The biological function of Thy-1 ranges from T cell activation, cell adhesion, neurite growth, differentiation, metastasis and fibrogenesis and has been extensively reviewed elsewhere. However, current discoveries implicate Thy-1 also functions as a key mechanotransduction mediator. In this review, we will be focusing on the role of Thy-1 in translating extracellular mechanic cues into intracellular biological cascades. The mechanotransduction capability of Thy-1 relies on <italic>trans</italic> and <italic>cis</italic> interaction between Thy-1 and RGD-binding integrins; and will be discussed in depth in the review.</p>