AUTHOR=Hou Wei , Syn Wing-Kin 

TITLE=Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=6

YEAR=2018

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2018.00150

DOI=10.3389/fcell.2018.00150

ISSN=2296-634X

ABSTRACT=<p>Activation of hepatic stellate cell (HSC) involves the transition from a quiescent to a proliferative, migratory, and fibrogenic phenotype (i.e., myofibroblast), which is characteristic of liver fibrogenesis. Multiple cellular and molecular signals which contribute to HSC activation have been identified. This review specially focuses on the metabolic changes which impact on HSC activation and fibrogenesis.</p>