AUTHOR=Mayr Vanessa , Sturtzel Caterina , Stadler Manuela , Grissenberger Sarah , Distel Martin TITLE=Fast Dynamic in vivo Monitoring of Erk Activity at Single Cell Resolution in DREKA Zebrafish JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=6 YEAR=2018 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2018.00111 DOI=10.3389/fcell.2018.00111 ISSN=2296-634X ABSTRACT=
Precise regulation of signaling pathways in single cells underlies tissue development, maintenance and repair in multicellular organisms, but our ability to monitor signaling dynamics in living vertebrates is currently limited. We implemented kinase translocation reporter (KTR) technology to create DREKA (“