AUTHOR=Mukherjee Angana , Hollern Daniel P. , Williams Oluwasina G. , Rayburn Tyeler S. , Byrd William A. , Yates Clayton , Jones Jacqueline D. 

TITLE=A Review of FOXI3 Regulation of Development and Possible Roles in Cancer Progression and Metastasis

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=6

YEAR=2018

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2018.00069

DOI=10.3389/fcell.2018.00069

ISSN=2296-634X

ABSTRACT=<p>Development and cancer share a variety of functional traits such as EMT, cell migration, angiogenesis, and tissue remodeling. In addition, many cellular signaling pathways are noted to coordinate developmental processes and facilitate aspects of tumor progression. The Forkhead box superfamily of transcription factors consists of a highly conserved DNA binding domain, which binds to specific DNA sequences and play significant roles during adult tissue homoeostasis and embryogenesis including development, differentiation, metabolism, proliferation, apoptosis, migration, and invasion. Interestingly, various studies have implicated the role of key Fox family members such as <italic>FOXP, FOXO</italic>, and <italic>FOXA</italic> during cancer initiation and metastases. <italic>FOXI3</italic>, a member of the Forkhead family affects embryogenesis, development, and bone remodeling; however, no studies have reported a role in cancer. In this review, we summarize the role of <italic>FOXI3</italic> in embryogenesis and bone development and discuss its potential involvement in cancer progression with a focus on the bone metastasis. Moreover, we hypothesize possible mechanisms underlying the role of <italic>FOXI3</italic> in the development of solid tumor bone metastasis.</p>