AUTHOR=Welburn Julie P. I. , Jeyaprakash A. Arockia 

TITLE=Mechanisms of Mitotic Kinase Regulation: A Structural Perspective

JOURNAL=Frontiers in Cell and Developmental Biology

VOLUME=6

YEAR=2018

URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2018.00006

DOI=10.3389/fcell.2018.00006

ISSN=2296-634X

ABSTRACT=<p>Protein kinases are major regulators of mitosis, with over 30% of the mitotic proteome phosphorylated on serines, threonines and tyrosines. The human genome encodes for 518 kinases that have a structurally conserved catalytic domain and includes about a dozen of cell division specific ones. Yet each kinase has unique structural features that allow their distinct substrate recognition and modes of regulation. These unique regulatory features determine their accurate spatio-temporal activation critical for correct progression through mitosis and are exploited for therapeutic purposes. In this review, we will discuss the principles of mitotic kinase activation and the structural determinants that underlie functional specificity.</p>