AUTHOR=Martín-Martín Natalia , Carracedo Arkaitz , Torrano Verónica TITLE=Metabolism and Transcription in Cancer: Merging Two Classic Tales JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=5 YEAR=2018 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2017.00119 DOI=10.3389/fcell.2017.00119 ISSN=2296-634X ABSTRACT=

Cellular plasticity, or the ability of a cancer cell to adapt to changes in the microenvironment, is a major determinant of cell survival and functionality that require the coordination of transcriptional programs with signaling and metabolic pathways. In this scenario, these pathways sense and integrate nutrient signals for the induction of coordinated gene expression programs in cancer. This minireview focuses on recent advances that shed light on the bidirectional relationship between metabolism and gene transcription, and their biological outcomes in cancer. Specifically, we will discuss how metabolic changes occurring in cancer cells impact on gene expression, both at the level of the epigenetic landscape and transcription factor regulation.