AUTHOR=Liu Chun , Himmati Farhan , Sayed Nazish TITLE=Paying the Toll in Nuclear Reprogramming JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=5 YEAR=2017 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2017.00070 DOI=10.3389/fcell.2017.00070 ISSN=2296-634X ABSTRACT=

The ability to reverse lineage-committed cells toward pluripotent stem cells or to another cell type is one of the ultimate goals in regenerative medicine. We recently discovered that activation of innate immunity, through Toll-like receptor 3, is required during this conversion of cell fate by causing global changes in the expression and activity of epigenetic modifiers. Here we discuss, in a comprehensive manner, the recent studies on the role of innate immunity in nuclear reprogramming and transdifferentiation, the underlying mechanisms, and its role in regenerative medicine.