AUTHOR=te Winkel J. Derk , Gray Declan A. , Seistrup Kenneth H. , Hamoen Leendert W. , Strahl Henrik TITLE=Analysis of Antimicrobial-Triggered Membrane Depolarization Using Voltage Sensitive Dyes JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=4 YEAR=2016 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2016.00029 DOI=10.3389/fcell.2016.00029 ISSN=2296-634X ABSTRACT=
The bacterial cytoplasmic membrane is a major inhibitory target for antimicrobial compounds. Commonly, although not exclusively, these compounds unfold their antimicrobial activity by disrupting the essential barrier function of the cell membrane. As a consequence, membrane permeability assays are central for mode of action studies analysing membrane-targeting antimicrobial compounds. The most frequently used