AUTHOR=Wallner Stephanie , Peters Sebastian , Pitzer Claudia , Resch Herbert , Bogdahn Ulrich , Schneider Armin TITLE=The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=3 YEAR=2015 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2015.00048 DOI=10.3389/fcell.2015.00048 ISSN=2296-634X ABSTRACT=

Granulocyte-colony stimulating factor (G-CSF) is a growth factor that has originally been identified several decades ago as a hematopoietic factor required mainly for the generation of neutrophilic granulocytes, and is in clinical use for that. More recently, it has been discovered that G-CSF also plays a role in the brain as a growth factor for neurons and neural stem cells, and as a factor involved in the plasticity of the vasculature. We review and discuss these dual properties in view of the neuroregenerative potential of this growth factor.