AUTHOR=Ozturk Nihan , Singh Indrabahadur , Mehta Aditi , Braun Thomas , Barreto Guillermo TITLE=HMGA proteins as modulators of chromatin structure during transcriptional activation JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=2 YEAR=2014 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2014.00005 DOI=10.3389/fcell.2014.00005 ISSN=2296-634X ABSTRACT=

High mobility group (HMG) proteins are the most abundant non-histone chromatin associated proteins. HMG proteins bind to DNA and nucleosome and alter the structure of chromatin locally and globally. Accessibility to DNA within chromatin is a central factor that affects DNA-dependent nuclear processes, such as transcription, replication, recombination, and repair. HMG proteins associate with different multi-protein complexes to regulate these processes by mediating accessibility to DNA. HMG proteins can be subdivided into three families: HMGA, HMGB, and HMGN. In this review, we will focus on recent advances in understanding the function of HMGA family members, specifically their role in gene transcription regulation during development and cancer.