AUTHOR=Puchľová Eva , Hilberath Thomas , Vranková Kvetoslava , Hollmann Frank 

TITLE=Towards Biocatalytic Oxidation of Secondary Alcohols to Carbonyl Products of Relevance for Flavors and Fragrances

JOURNAL=Frontiers in Catalysis

VOLUME=2

YEAR=2022

URL=https://www.frontiersin.org/journals/catalysis/articles/10.3389/fctls.2022.926316

DOI=10.3389/fctls.2022.926316

ISSN=2673-7841

ABSTRACT=<p>Non-enantioselective alcohol dehydrogenases (ADHs) are rarely found in the biocatalysis portfolio. Generally, highly enantioselective ADHs are sought for. Using such ADHs for the oxidation of racemic alcohols generally results in a kinetic resolution of the starting material, which is unfavourable if the ketone represents the product of interest. In the current contribution we report the ADH from <italic>Sphingobium yanoikuyae</italic> (<italic>Sy</italic>ADH) as non-enantioselective ADH for the complete oxidation or <italic>rac</italic>-heptan-2-ol (representing further 2-alkanols).</p>