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Published on 24 Oct 2024

Simultaneous determination of the combined and free concentrations of atorvastatin and its major metabolite in vitro and in vivo based on ultrafiltration coupled with UPLC-MS/MS method: an application in a protein binding rate and metabolism ability study in uremic hemodialysis patients

in Cardiovascular Pharmacology and Drug Discovery

  • Ming-Chen Cao
  • Xin Huang
  • Bo-Hao Tang
  • Hai-Yan Shi
  • Yi Zheng
  • Wei Zhao
Simultaneous determination of the combined and free concentrations of atorvastatin and its major metabolite in vitro and in vivo based on ultrafiltration coupled with UPLC-MS/MS method: an application in a protein binding rate and metabolism ability study in uremic hemodialysis patients
Frontiers in Cardiovascular Medicine
doi 10.3389/fcvm.2024.1461181
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