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MINI REVIEW article
Front. Cardiovasc. Med.
Sec. Heart Failure and Transplantation
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1573346
Evolving Role of Myocardial Fibrosis in Heart Failure with Preserved Ejection Fraction
Provisionally accepted- 1Baylor Scott and White The Heart Hospital, Plano, United States
- 2Loyola University Medical Center, Maywood, Illinois, United States
- 3Division of Cardiology, Rush Medical College, Rush University, Chicago, Illinois, United States
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Heart failure with preserved ejection fraction (HFpEF) is a complex clinical diagnosis with a heterogeneous pathophysiology and clinical presentation. The hallmark of HFpEF is diastolic dysfunction associated with left ventricular remodeling and fibrosis. Myocardial interstitial fibrosis (MIF) occurs as the result of collagen deposition and is dependent on the underlying etiology of heart failure. Detection of MIF can be done by invasive histopathologic sampling or by imaging. More recently, novel biomarkers have been investigated as an alternative tool for not only the detection of MIF but also for the prognostication of patients with HFpEF which may in turn alleviate the need for invasive and expensive imaging in the future.
Keywords: Heart failure with preserved ejection, Myocardial fibrosis, Inflammation, biomarkers, Collagen metabolism
Received: 08 Feb 2025; Accepted: 07 Apr 2025.
Copyright: © 2025 Malik, Kinno, Liebo, Yu and Syed. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mushabbar Syed, Loyola University Medical Center, Maywood, 60153, Illinois, United States
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.