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ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Thrombosis and Haemostasis
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1566635
This article is part of the Research Topic Prognostic Value of Inflammatory and Thrombotic Biomarkers in Acute Coronary Syndrome View all 3 articles
Increased monocytes and their derived indicators are associated with clinical severity of acute heart failure following acute myocardial infarction
Provisionally accepted- Affiliated Hospital and Clinical Medical College of Chengdu University, Chengdu, China
Objective: Monocytes play a significant role in the pathophysiology of acute myocardial infarction (AMI). The relationship between monocytes, their derived indicators, and the severity of acute heart failure following AMI remains unclear. Therefore, this study aims to investigate the association of monocytes and their derived indicators with clinical severity of acute heart failure in the patients with AMI.Methods: In total of 173 patients with AMI were enrolled in this retrospective study. The demographic data and relevant medical histories were obtained. Monocytes and lipid levels were measured. All patients were divided into two groups based on killip classification. Killip class III-IV is defined as acute severe heart failure, while killip class I-II is defined as acute non-severe heart failure.Results: Monocyte count, monocyte-to-white blood cell ratio, and monocyte-to-lymphocyte ratio were significantly higher in patients with acute severe heart failure compared to those with acute nonsevere heart failure (P<0.05). Multivariate logistic regression analysis showed that monocyte count, monocyte-to-white blood cell ratio, and monocyte-to-lymphocyte ratio were independently associated with acute severe heart failure (P<0.05). Moreover, monocyte count, monocyte-to-white blood cell ratio, and monocyte-to-lymphocyte ratio were linked to NT-proBNP concentrations (P<0.05). Receiver-operating characteristic curve analysis showed that monocyte count, monocyteto-white blood cell ratio, and monocyte-to-lymphocyte ratio could identify acute severe heart failure in patients following AMI to some extent (P < 0.05).The elevation of monocyte count, monocyte-to-white blood cell ratio, and monocyte-tolymphocyte ratio correlated with clinical severity of acute heart failure following AMI, and offered potential discriminating value for cardiogenic pulmonary edema and shock following AMI.
Keywords: acute myocardial infarction, Monocytes, monocyte-to-white blood cell ratio, monocyteto-lymphocyte ratio, acute heart failure
Received: 25 Jan 2025; Accepted: 24 Mar 2025.
Copyright: © 2025 Xiong, An, Yuan, Long and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xinlin Xiong, Affiliated Hospital and Clinical Medical College of Chengdu University, Chengdu, China
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