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ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Imaging
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1558800
This article is part of the Research TopicRevolutionizing Cardiovascular Diagnosis: Advances in Functional Imaging TechnologiesView all 9 articles
Assessment of right ventricular involvement in patients with anti-MDA5 Ab+ DM，a prospectively observational study with Cardiac Magnetic Resonance Imaging
Provisionally accepted
Ling Zhang1Yuli Wang1Jinzhu Dai1Xiaoqi Pu1Anqi Liui2Yifei Ni2Jianping Wang3Jie Du2
Yanhong Ren1
Xiaoming Shu1
Min Liu1*- 1China-Japan Friendship Hospital, Beijing, China
- 2Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, Beijing Municipality, China
- 3Capital Medical University, Beijing, Beijing Municipality, China
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Background: Anti-melanoma differentiation-associated gene 5 dermatomyositis (anti-MDA5 Ab+ DM) is characterized by amyopathic DM with interstitial lung disease. Its impact on right ventricle remains unclear. We aim to evaluate RV involvement in anti-MDA5 Ab+ DM patients using cardiovascular magnetic resonance (CMR). Methods: This single-center, prospective cohort study included 43 anti-MDA5 Ab+ DM patients (24 males, mean age 44.7 ± 11.1 years) and 30 age-and gender-matched healthy controls (18 males, mean age 44.8 ± 10.4 years). All patients underwent CMR before treatment. RV functional parameters, including ejection fraction (RVEF), end-diastolic/end-systolic remodeling index (RVEDRI/RVESRI), and right ventricular long-axis strain (RV-LAS), RV and LV T1 and T2 Mapping were analyzed. Differences between two groups were evaluated, and correlations with clinical data were explored.Results: Anti-MDA5 Ab+ DM patients exhibited a significant decrease in RVEF (45.7 ± 5.9% vs. 52.7 ± 6.6%, P < 0.001) and RV-LAS across all techniques. Increased RVESRI (1.38 ± 0.14 vs.1.29 ± 0.14, P = 0.031) indicated RV subclinical dysfunction. The RV and LV blood pool T2 ratio was elevated in patients (0.96 ± 0.02 vs. 0.94 ± 0.03, P = 0.007). Patients in inflammatory markerpositive group exhibited significantly worse RV-LAS compared to the negative group. RV-LASIns/mid negatively correlated with hsTnl levels] (r = -0.34, P = 0.026), andferritin (FER) is moderately positively correlated with RV-LASLVapex/peri (r = 0.487, P < 0.001)).with anti-MDA5 Ab+ DM patients. RV parameters on CMR such as RV-LAS and RVESRI serve as valuable imaging markers for early detection and risk stratification. These findings underscore the importance of routine cardiac evaluation in anti-MDA5 Ab+ DM.
Keywords: MDA5 + DM, right ventriclar function, right ventricular long-axis strain (RV-LAS), end-diastolic remodeling index, T1 Mapping, T2 mapping
Received: 11 Jan 2025; Accepted: 17 Apr 2025.
Copyright: © 2025 Zhang, Wang, Dai, Pu, Liui, Ni, Wang, Du, Ren, Shu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Min Liu, China-Japan Friendship Hospital, Beijing, China
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