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ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Imaging
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1553919
This article is part of the Research TopicArtificial Intelligence for Myocardial Tissue Characterization in Cardiac Magnetic ResonanceView all articles
Scanner-generated native T1 Mapping: A Novel Approach for Assessing Myocardial Fibrosis in
Provisionally accepted- 1Chongqing Medical University, Chongqing, China
- 2Southwest Hospital, Army Medical University, Chongqing, China
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To investigate the feasibility of using native longitudinal relaxation time (T1) mapping values, derived from the Picture Archiving and Communication System (PACS), for assessing diffuse myocardial fibrosis in patients with coronary heart disease (CHD).Patients with CHDgroup were retrospectively enrolled as the experimental group, while age-and sex-matched healthy individuals were included as the control group. Based on the results of late gadolinium enhancement (LGE) sequence from cardiac magnetic resonance (CMR) imaging, the CHD group was further stratified into two subgroups: the LGE-positive group (LGE+) and the LGE-negative group (LGE-). The correlation between native T1 values and extracellular volume (ECV) values were assessed using the Pearson correlation coefficient.Results： A total of 60 patients with coronary heart disease (age 54.03 ± 9.86 years) were included in the analysis, of whom 30 had late gadolinium enhancement (LGE+) and 30 did not (LGE-). The control group consisted of 42 healthy subjects (age 52.14 ± 7.41 years). Compared with the control group, both native T1 and extracellular volume (ECV) values were significantly increased in the CHD group (P < 0.05). The native T1 value was positively correlated with the ECV value (r = 0.711, P < 0.01). In theLGE+ subgroup, native T1 and ECV values were significantly higher than those in the control group (P < 0.001). The area under the receiver operating characteristic curve (AUC) for native T1 was 0.76. The optimal diagnostic threshold for native T1, as measured by the Picture Archiving and Communication System (PACS), was 1275.50 ms, with a sensitivity of 93.3% and a specificity of 63.3%.The diagnostic performance of scanner-generated native T1 Mapping demonstrates robust accuracy and holds potential as a non-invasive tool for evaluating diffuse myocardial fibrosis in patients with coronary heart disease (CHD).
Keywords: Hematocrit, invasive coronary angiography, ECV, coronary heart disease, CMR, PACS
Received: 31 Dec 2024; Accepted: 11 Apr 2025.
Copyright: © 2025 Kong, Tian, Ji, Wang, Liang and Ji. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hongqin Liang, Southwest Hospital, Army Medical University, Chongqing, 400038, China
Xiaojuan Ji, Chongqing Medical University, Chongqing, 400016, China
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