Skip to main content

ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Atherosclerosis and Vascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1545927
This article is part of the Research Topic Cardiovascular calcification: disease mechanisms, clinical phenotypes and therapeutic strategies View all articles

The Naples Prognostic Score as a New Predictive Index of Severe Abdominal Aortic Calcification: a Population-Based Study

Provisionally accepted
Qiang Tan Qiang Tan Jian Zhang Jian Zhang Yanrong Peng Yanrong Peng Rui Yang Rui Yang Yanbin Zhu Yanbin Zhu Xi Yong Xi Yong Hongshun Yin Hongshun Yin Jianghua Zheng Jianghua Zheng *
  • Affiliated Hospital of North Sichuan Medical College, Nanchong, China

The final, formatted version of the article will be published soon.

    Abdominal aortic calcification (AAC) is related to inflammation and nutritional status. The Naples Prognostic Score (NPS) is an innovative biological marker capable of reflecting systemic inflammation and nutritional status. This research seeks to investigate the correlation of NPS with severe abdominal aortic calcification (SAAC). Methods: The research evaluated data obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2014. The variables were filtered utilizing the Least Absolute Shrinkage and Selection Operator (LASSO) regression. Weighted logistic regression models were employed to examine the association of NPS with SAAC. The predictive value of NPS for the risk of SAAC was assessed utilizing the receiver operating characteristic (ROC) curve. A subgroup analysis was conducted to assess the strength and reliability of the research findings.Results: The research encompassed 2,854 participants, among whom 303 (11.87%) exhibited SAAC. The outcomes of multivariate weighted logistic regression revealed that participants with a NPS of 3-4 points was positively correlated with SAAC in comparison to the control group (odds ratio (OR)=2.07, 95% confidence interval (95%CI): 1.17-3.67). The area under the curve (AUC) for predicting the risk of SAAC using NPS was 0.635. The subgroup analysis results indicated that there was no significant difference noted in the association of NPS with SAAC across various population subgroups.A positive association of NPS with SAAC has been observed in this research. This study offers valuable insights into the prevention and diagnosis of SAAC. Future longitudinal studies are warranted to confirm causative relationships and assess the role of NPS in clinical decision-making for SAAC.

    Keywords: Naples prognostic score, ABDOMINAL AORTIC CALCIFICATION, cardiovascular disease, NHANES, Cross-sectional study

    Received: 16 Dec 2024; Accepted: 03 Feb 2025.

    Copyright: © 2025 Tan, Zhang, Peng, Yang, Zhu, Yong, Yin and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jianghua Zheng, Affiliated Hospital of North Sichuan Medical College, Nanchong, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.