Changing performance of surgical risk scores according to the endpoint of postoperative mortality in3 infective endocarditis patients

Giuseppe Gatti ^1,2* Antonio Fiore ³ Maria Ismail ⁴ Igor Vendramin ⁵ Alessandro Minati ⁶ Gianfranco Sinagra ¹ Andrea Perrotti ⁴ Enzo Mazzaro ¹

• ¹ Azienda Sanitaria Università Integrata di Trieste, Trieste, Friuli-Venezia Giulia, Italy
• ² University of Trieste, Trieste, Friuli-Venezia Giulia, Italy
• ³ Faculté de Santé, Université Paris-Est Créteil Val de Marne, Paris, Ile-de-France, France
• ⁴ Centre Hospitalier Universitaire de Besançon, Besancon, Franche-Comté, France
• ⁵ University of Udine, Udine, Italy
• ⁶ Sapienza University of Rome, Rome, Lazio, Italy

The optimal endpoint for reporting early mortality after cardiac operations for infective endocarditis (IE), as well as the optimal mortality target for surgical risk scores, are unresolved questions.Methods: Five risk scores created specifically to predict early mortality after cardiac operations for definite IE, and the European System for Cardiac Operative Risk Evaluation II, were assessed in terms of calibration, discrimination and accuracy in predicting early mortality following cardiac surgery for IE. The evaluation was based on five definite endpoints of postoperative mortality: In-hospital, 30-day, inhospital/30-day, six-month, and one-year mortality. The six risk scores were tested in a population of 991 patients with definite IE who underwent 1,014 cardiac operations at five European university-affiliated centers.Results: There were 133 (13.1%) hospital deaths after surgery. Overall, 10% of patients died within 30 days after surgery, 10.4% of survivors died between 30 days and six months after surgery, and another 5.5% between six months and one year after surgery. All risk scores showed good prediction accuracy and at least acceptable discrimination for all endpoints of postoperative mortality. However, only one (IEspecific) risk score exhibited acceptable calibration for every endpoint of postoperative mortality.Since mortality decreases slowly throughout the first year after cardiac surgery for IE, it may be appropriate to report both in-hospital and one-year mortality (coupled endpoint) for this condition.For both endpoints, only one of the risk scores considered in this study showed acceptable calibration and discrimination.