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HYPOTHESIS AND THEORY article
Front. Cardiovasc. Med.
Sec. Cardiovascular Biologics and Regenerative Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1540051
Elucidating the Preventive and Therapeutic Effects of Cardiac Telocytes Paracrine microRNAs on Ischemic Heart Disease
Provisionally accepted
Hugang Jiang 1*
Ai Liu 1 Yan Tang 1
Chunzhen Ren 1 Wenyan Lin 2 Kai Liu 1* Xinke Zhao 3* Yingdong Li 1*- 1 Gansu University of Chinese Medicine, Lanzhou, China
- 2 Gansu Provincial Hospital, Lanzhou, Gansu Province, China
- 3 Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu Province, China
Telocytes (TCs), a newly identified type of mesenchymal cell since 2010, possess substantial potential in maintaining tissue homeostasis, orchestrating organ development, and facilitating tissue regeneration. Their distribution in blood, the adventitia of blood vessels, and the intima implies a close association with vascular function. Ischemic heart disease (IHD), a significant challenge in cardiovascular disease, is characterized by the occlusion of major vessels, obstruction of collateral circulation, and disruption of the capillary networkpathological features closely linked to endothelial cell damage. Myocardial tissue is rich in cardiac telocytes (cTCs), which, following myocardial injury, can secrete numerous miRNAs that promote angiogenesis, including miR-let-7e, miR-10a, and miR-126-3p. This indicates that cTCs may have therapeutic potential for IHD. The primary mechanism by which cTCs-derived exosomes exert paracrine effects is through reducing endothelial cell injury, suggesting that enhancing the production of cTCs could offer a novel therapeutic approach for treating IHD.
Keywords: Cardiac telocytes, paracrine secretions, Endothelial Cells, Crosstalk mechanism, IHD
Received: 17 Dec 2024; Accepted: 24 Feb 2025.
Copyright: © 2025 Jiang, Liu, Tang, Ren, Lin, Liu, Zhao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hugang Jiang, Gansu University of Chinese Medicine, Lanzhou, China
Kai Liu, Gansu University of Chinese Medicine, Lanzhou, China
Xinke Zhao, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, 730020, Gansu Province, China
Yingdong Li, Gansu University of Chinese Medicine, Lanzhou, China
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