Skip to main content

ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1538643
This article is part of the Research Topic Innovative Nutritional Strategies for Cardiovascular Health in Aging Populations View all articles

Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional study

Provisionally accepted
Ruicong Ma Ruicong Ma 1Jinyi Ren Jinyi Ren 2*Xianmei Chen Xianmei Chen 2*Xia Li Xia Li 2Ying Zhao Ying Zhao 2*Yanchun Ding Yanchun Ding 1*
  • 1 Second Affiliated Hospital of Dalian Medical University, Dalian, China
  • 2 Dalian Medical University, Dalian, Liaoning, China

The final, formatted version of the article will be published soon.

    elderly population: a cross-sectional study Abstract： Background: Systemic inflammation, immune and nutrition status are closely linked to the occurrence and development of coronary heart disease (CHD). Pan-immune-inflammation value (PIV)is a new method for evaluating systemic inflammation and immune status. Our objective is to explore the connection between PIV and CHD especially in elderly people, as well as the diagnostic value of PIV combined with controlling nutritional status (COUNT) score for CHD.Participants eligible for the study were sourced from NHANES data from 1999 to 2018.Logistic regression models were employed to evaluate the link between PIV and CHD. Additionally, restricted cubic spline was utilized to explore the correlations. Subgroup analysis was adopted in order to ensure the credibility of the results. The receiver operator characteristic (ROC) curve was used to explore the predictive value of PIV combined with COUNT score for CHD.Results: 41,713 individuals qualified for analysis. The individuals with CHD had higher levels of PIV.In the logistic regression model, PIV was positively related to CHD (Q4 vs. Q1, OR =1.23 (1.03-1.48, P<0.001)). Restricted cubic spline indicated a positive non-linear relationship (P for overall<0.001, P for non-linear=0.009). However, restricted cubic spline shows that this positive correlation is only significant in the elderly population aged 60 and above. Subgroup analysis shows that the relationship between PIV and CHD is more significant in the elderly population (P<0.001). The ROC curve shows that PIV has better diagnostic value for CHD than other common inflammatory indicators.Furthermore, the combination of PIV and COUNT score is superior to PIV or COUNT score.A positive link between PIV and CHD, especially in the elderly. The combination of PIV and COUNT score has better diagnostic value for CHD.

    Keywords: coronary heart disease, NHANES, Pan-Immune-Inflammation Value, Controlling Nutritional Status score, elderly people

    Received: 03 Dec 2024; Accepted: 13 Jan 2025.

    Copyright: © 2025 Ma, Ren, Chen, Li, Zhao and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jinyi Ren, Dalian Medical University, Dalian, 116044, Liaoning, China
    Xianmei Chen, Dalian Medical University, Dalian, 116044, Liaoning, China
    Ying Zhao, Dalian Medical University, Dalian, 116044, Liaoning, China
    Yanchun Ding, Second Affiliated Hospital of Dalian Medical University, Dalian, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.