Understanding the Hidden Burden: Prevalence and Factors Linked to Left Ventricular Hypertrophy in Hypertensive Patients Receiving Care in Harari Region, Ethiopia

Dawit Abebe ^1* Ashenafi Tadesse ² Zerihun Abera Ayele ³ Megnot Hailu Mekonnen ¹ Sinetibeb Mesfin ⁴

• ¹ School of Nursing and Midwifery, College of Medicine and Health Sciences, Jigjiga University, Jigjiga, Ethiopia
• ² School Medicine, College of Medicine and Health Sciences, Haramaya University, Harar, Ethiopia, School of Medicine, College of Health and Medical Sciences, Haramaya University, Dire Dawa, Dire Dawa, Ethiopia
• ³ School of Medicine, Institute of Health, Jigjiga University, Jigjiga, Ethiopia
• ⁴ School of Nursing and Midwifery, College of Health and Medical Sciences, Haramaya University,, Harar, Ethiopia

Background: Left ventricular hypertrophy is often a complication of hypertension and an independent risk factor for cardiovascular events. In Ethiopia, there is a scarcity of data on the prevalence and associated factors of left ventricular hypertrophy among hypertensive adults. The aim of this study was to assess the prevalence and associated factors of left ventricular hypertrophy among adult patients with hypertension attending treatment at two public hospitals in Harar, Eastern Ethiopia from December 20, 2021, to December 20, 2023.Method: A hospital-based cross-sectional study was conducted on 264 hypertensive patients from December 20, 2021, to December 20, 2023. A pretested structured questionnaire and checklist were used to collect data from participants and their clinical records. The data was collected by trained residents, and interns. Data were analyzed using SPSS version 29. Left ventricular mass was measured by transthoracic echocardiography. Associations between categorical variables were assessed using a chi-square test and odds ratio with 95% confidence interval. A logistic regression model was used to identify risk factors of LVH. P values of < 0.05 were considered as statistically significant. Results: The study included 264 adults with hypertension, with a mean age of 58.4 years, and the majority (54.5%) were male. The prevalence of echocardiographically confirmed left ventricular hypertrophy (LVH) was 30.7% (95% CI: 25.1%–36.3%), with mild LVH being the most common type (51%). Significant predictors of LVH included age over 60 years (AOR=5.981, CI=1.832–19.522, P=0.003), khat chewing (AOR=2.676, CI=1.786–9.109, P=0.001), diabetes (AOR=10.430, CI=2.904–37.454, P<0.001), poor medication adherence (AOR=4.132, CI=1.208–14.141, P=0.024), uncontrolled systolic blood pressure (AOR=8.340, CI=2.280–30.512, P=0.001), lack of home blood pressure monitoring (AOR=5.591, CI=1.041–30.012, P=0.045), and longer hypertension duration (AOR=8.766, CI=2.101–36.584, P=0.003). These findings emphasize the need to address modifiable risk factors in managing hypertension to reduce the burden of LVH.Conclusions: The echocardiographic prevalence of LVH was 30.7% in the study population. These results highlight the importance of addressing modifiable risks to reduce LVH burden.Key Words: Hypertension, left ventricular hypertrophy, Echocardiography, Ethiopia