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REVIEW article
Front. Cardiovasc. Med.
Sec. Cardiovascular Biologics and Regenerative Medicine
Volume 12 - 2025 |
doi: 10.3389/fcvm.2025.1533105
Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair
Provisionally accepted- 1 Qingdao University, Qingdao, China
- 2 Jinan Provincial Laboratory of Microecology and Biomedicine, Jinan, Shandong Province, China
Cardiovascular diseases are the most lethal diseases worldwide, of which myocardial infarction is the leading cause of death. After myocardial infarction, in order to ensure normal blood supply to the heart, the remaining cardiomyocytes compensate for the loss of cardiomyocytes mainly by working at high capacity rather than by proliferating to produce new cardiomyocytes. This is partly due to the extremely limited ability of the adult heart to repair itself. A growing body of research suggests that the loss of cardiac regenerative capacity is closely related to metabolic shifts in energy sources. Currently, a large number of studies have focused on changes in metabolic levels before and after the proliferation window of cardiomyocytes, so it is crucial to search for relevant factors in metabolic pathways to regulate the cell cycle in cardiomyocyte progression. This paper presents a review of the role of myocardial energy metabolism in regenerative repair after cardiac injury. It aims to elucidate the effects of myocardial metabolic shifts on cardiomyocyte proliferation in adult mammals and to point out directions for cardiac regeneration research and clinical treatment of myocardial infarction.
Keywords: Myocardial Infarction, cardiomyocyte proliferation, Cardiac regeneration, Energy Metabolism, Cell Cycle
Received: 23 Nov 2024; Accepted: 27 Jan 2025.
Copyright: © 2025 Ren, Xinzhe, Wang, Liu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiahao Ren, Qingdao University, Qingdao, China
Cuiyun Liu, Qingdao University, Qingdao, China
Kun Wang, Qingdao University, Qingdao, China
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