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REVIEW article
Front. Cardiovasc. Med.
Sec. Lipids in Cardiovascular Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1529924
Crosstalk Between Lipid Metabolism and Macrophages in Atherosclerosis: Therapeutic Potential of Natural Products
Provisionally accepted- 1 Heilongjiang University of Chinese Medicine, Harbin, China
- 2 First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
- 3 Heilongjiang Institute of Meteorological Sciences, Heilongjiang Meteorological Bureau, Harbin, Heilongjiang Province, China
Atherosclerosis is a highly prevalent cardiovascular condition that affects individuals worldwide. Despite ongoing research into its treatment and prevention, atherosclerotic cardiovascular disease continues to exhibit high morbidity and mortality rates. The accumulation of low-density lipoprotein cholesterol is considered a major contributor to the development of atherosclerosis, with abnormalities in lipid metabolism playing a significant role in its pathogenesis.Lipid metabolism and macrophage function are intricately interconnected, with lipid metabolism being influenced by macrophage inflammatory responses, while macrophage activity is regulated by alterations in lipid metabolism. The interaction between these two processes plays a critical role in the progression of atherosclerosis. Natural products have shown considerable promise in treating a variety of diseases, including atherosclerosis. Moreover, the modulation of lipid metabolism and macrophage crosstalk represents a key mechanism through which natural products may exert their effects. This research aims to provide new insights into the current state of research on the role of natural products in regulating this pathway and the interplay between lipid metabolism and macrophages in the context of atherosclerosis, offering potential directions for the future.
Keywords: Atherosclerosis, Lipids, Macrophages, Natural drug, Metabolism
Received: 10 Dec 2024; Accepted: 17 Feb 2025.
Copyright: © 2025 Qian, Guo, Sun, Chi, Ma and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Juan Jin, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.