ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1529533
Association between The Red Blood Cell Distribution Width-Albumin Ratio and Cardiovascular Diseases
Provisionally accepted
- 1 Lanzhou University Second Hospital, Lanzhou, China
- 2 Lanzhou University, Lanzhou, Gansu Province, China
- 3 Rongchang Traditional Chinese Medicine Hospital, Rongchang, Chongqing, China
You have multiple emails registered with Frontiers:
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Cardiovascular disease (CVD) is the major cause of death globally, ranking first in terms of morbidity and mortality among non-communicable diseases. Red blood cell distribution width (RDW) and albumin (ALB) possess potential clinical application values. Moreover, the ratio of the two, namely RAR, might hold more advantages in disease diagnosis. However, the relationship between RAR and CVD in the general population has not been studied yet.Method: This represents a study encompassing 12,765 subjects. Logistic regression, Cox regression, restricted cubic splines, mediation analysis, and receiver operating characteristic curves were utilized to probe into the association between RAR and CVD, cardiovascular mortality rate and all -cause mortality rate.Result: A total of 12,765 participants were enrolled in this study, The mean age was 47.47±16.33 years. logistic regression revealed that RAR was positively correlated with the CVD. Furthermore, COX regression also illustrated that RAR was non -linearly and positively associated with both all -cause mortality rate and cardiovascular mortality rate (all -cause mortality: p-non-linear=0.0322; cardiovascular mortality: p-non-linear=0.0280). Additionally, the ROC results indicated that at various time points, RAR exhibited a stronger discriminatory capacity for cardiovascular mortality rate compared to all -cause mortality rate. HbA1c partially mediated the relationship between RAR and CVD. Subgroup analysis and interaction findings demonstrated that hypertension and race exerted a significant influence on the relationship between RAR and both all -cause mortality rate and cardiovascular mortality rate.Conclusion: RAR was significantly linked to an elevated risk of CVD. The higher the RAR level, the greater the cardiovascular mortality rate and all -cause mortality rate. Thus, RAR could potentially be an independent risk factor for CVD. This underscores the crucial value of RAR in the discrimination and management of CVD.
Keywords: The red blood cell distribution width-to-albumin ratio1, cardiovascular diseases2, all -cause mortality rate3, all -cause mortality rate4, inflammation5
Received: 17 Nov 2024; Accepted: 19 Mar 2025.
Copyright: © 2025 Liu, Sun and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shougang Sun, Lanzhou University Second Hospital, Lanzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
