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BRIEF RESEARCH REPORT article

Front. Cardiovasc. Med.
Sec. Cardiac Rhythmology
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1525762

Effects of Key Parameters on Pulsed Field Ablation of Atrial Fibrillation: Potato Experiments

Provisionally accepted
Yunhao Li Yunhao Li 1Fengqi Xuan Fengqi Xuan 2Daoyang Zhang Daoyang Zhang 1Mingyu Sun Mingyu Sun 1Ping Zhang Ping Zhang 1Qi Zhang Qi Zhang 1Jie Zhang Jie Zhang 1Yaling Han Yaling Han 1Zulu Wang Zulu Wang 1Ming Liang Ming Liang 3*
  • 1 General Hospital of Northern Theater Command, Shenyang, China
  • 2 Tianjin Chest Hospital, Tianjin, Tianjin Municipality, China
  • 3 Department of Cardiology, Northern Theater Command General Hospital, Shenyang, China

The final, formatted version of the article will be published soon.

    The study aims to investigate the impact of key parameters of pulsed field ablation (PFA) on lesion depth, including voltage (V), pulse width (PW), number of pulses (P), and ablation number (N), using potato models.METHODS: Potatoes are utilized as a display of the irreversible electroporation lesion. The key ablation parameters were varied systematically to explore its influences on lesion depths.The key ablation parameters have varying degrees of influence on lesion depths, following the order of PW > V; V > P; PW > P; N > P. Lesion depths increased with higher values of V and P. However, when the total number of pulses reached 9600, there was no significant increase in injury depth.

    Keywords: pulsed field ablation, Key parameters, Pre-clinical study, Pulmonary vein isolation, Tomato

    Received: 10 Nov 2024; Accepted: 20 Jan 2025.

    Copyright: © 2025 Li, Xuan, Zhang, Sun, Zhang, Zhang, Zhang, Han, Wang and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ming Liang, Department of Cardiology, Northern Theater Command General Hospital, Shenyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.