ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Hypertension
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1521087
This article is part of the Research TopicEmerging Molecules in Pulmonary Hypertension: Diagnosis, Risk Prediction, Treatment and PrognosisView all 4 articles
Identification of a PANoptosis-Related Gene Signature Reveals Therapeutic Potential of SFRP2 in Pulmonary Arterial Hypertension
Provisionally accepted
Li Li
Mirkamil Jurat*- Changsha Fourth Hospital, Changsha, China
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Background: Pulmonary arterial hypertension (PAH) is a serious condition marked by elevated pulmonary artery pressure, often progressing to right heart failure and high mortality. PANoptosis, an inflammatory form of programmed cell death, remains understudied in the context of PAH. This study aims to identify and validate PANoptosis-related signature genes in PAH using bioinformatics analysis alongside in vivo and in vitro experiments, seeking to uncover its potential role in disease progression.
Keywords: PANoptosis, pulmonary arterial hypertension, bioinformatics, sFRP2, Immune Cell Infiltration
Received: 01 Nov 2024; Accepted: 17 Apr 2025.
Copyright: © 2025 Li and Jurat. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mirkamil Jurat, Changsha Fourth Hospital, Changsha, China
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