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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Cardiovascular Surgery
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1519251

Association Between Cardiopulmonary Bypass Duration and Early Major Adverse Cardiovascular Events after Surgical Repair of Supravalvular Aortic Stenosis Running head: CPB Duration and postoperative MACE

Provisionally accepted
Simeng Zhang Simeng Zhang 1Caiyi Wei Caiyi Wei 2Bo Peng Bo Peng 3Lizhi Lv Lizhi Lv 4Fengbo Pei Fengbo Pei 1Jianming Xia Jianming Xia 5Jun Yan Jun Yan 3Jie Liu Jie Liu 6Qiang Wang Qiang Wang 4Yi Shi Yi Shi 1*
  • 1 Department of Cardiac Surgery, Peking University People's Hospital, Beijing, Beijing Municipality, China
  • 2 School of Basic Medical Sciences, Health Science Centre, Peking University, Beijing, Beijing Municipality, China
  • 3 Department of Cardiac Surgery, National Center for Cardiovascular Diseases and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
  • 4 Pediatric Cardiac Central Surgery, Beijing Anzhen Hopital, Capital Medical University, Beijing, China
  • 5 Yunnan Fuwai Cardiovascular Hospital, Kunming, Yunnan Province, China
  • 6 Department of Cardiovascular Surgery, PLA General Hospital, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Background: Patients who underwent surgical repair of supravalvular aortic stenosis (SVAS) are at high risk for postoperative major adverse cardiovascular events (MACE).This study aimed to investigate the association between cardiopulmonary bypass (CPB) duration and MACE occurring during postoperative hospitalization or within 30 days post-surgery. Methods: Patients who underwent surgical repair of SVAS from 2002 to 2019 at Beijing Fuwai Hospital and Yunnan Fuwai Hospital were included in this study. Patients were stratified into 'CPB duration >2 hours' and 'CPB duration ≤2 hours' groups based on intraoperative CPB duration. Various statistical methodologies were employed to investigate the association between CPB duration and early postoperative MACE, including multivariate adjustment, propensity score adjustment, propensity score matching, and logistic regression based on propensity score weighting.Results: 297 participants were included and 164 were finally matched. In the propensity score-matched cohort, CPB duration was positively associated with early postoperative MACE (odds ratio = 18.13; 95% confidence interval 2.33-140.86; P = 0.006). Consistent results were obtained in the Inverse probability of treatmentweighted, standardized mortality ratio-weighted, pairwise algorithmic-weighted, and overlap-weighted models.Patients with CPB duration >2 hours were at a higher risk of early postoperative MACE compared to those with CPB duration ≤2 hours. This emphasized the significance of minimizing CPB exposure for the prognosis of patients with SVAS.

    Keywords: Cardiopulmonary Bypass, Supravalvular aortic stenosis, Adverse cardiovascular events, Surgical therapy, Logistic regression analysis

    Received: 29 Oct 2024; Accepted: 02 Jan 2025.

    Copyright: © 2025 Zhang, Wei, Peng, Lv, Pei, Xia, Yan, Liu, Wang and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yi Shi, Department of Cardiac Surgery, Peking University People's Hospital, Beijing, 100044, Beijing Municipality, China

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