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CASE REPORT article
Front. Cardiovasc. Med.
Sec. Cardiac Rhythmology
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1516574
This article is part of the Research Topic New Challenges in Arrhythmology View all 11 articles
Cardiac Contractility Modulation as bridge to recovery in a patient with advanced heart failure candidate to left ventricular assist devices: a case report and review of literature
Provisionally accepted
Francesca Menichetti *
Marco Solari 
Elisa Salvetti Vincenzo Guarnaccia 
Tommaso Girasole Flavio Venturi Attilio Del Rosso - Azienda USL Toscana Centro, Firenze, Italy
This case report illustrates the effects of CCM as a bridge to recovery in a patient who has been a candidate for LVAD. After CCM the patient hase become stable in NYHA class II, with no further acute HF episodes and a significant clinical and functional improvements. Consequently, the patient was no longer an LVAD candidate, as CCM had acted as a bridge to recovery, making the advanced HF designation no longer applicable. The ease of implantation, uneventful procedural recovery, extraordinary device longevity, and favorable risk profile all position CCM as an important tool in the treatment of advanced HFrEF patients candidate to LVAD therapy, serving as a bridge to recovery.Further large-scale randomized controlled trials are needed to confirm the long-term benefits of CCM therapy in this particular population subgroup, helping a better patient selection.
Keywords: Cardiac Contractility Modulation (CCM), Advance heart failure, Bridge to recovery, Left ventricular assist devices (LVAD), Heart tranplantation
Received: 24 Oct 2024; Accepted: 07 Mar 2025.
Copyright: © 2025 Menichetti, Solari, Salvetti, Guarnaccia, Girasole, Venturi and Del Rosso. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Francesca Menichetti, Azienda USL Toscana Centro, Firenze, Italy
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