Skip to main content

CASE REPORT article

Front. Cardiovasc. Med.
Sec. Structural Interventional Cardiology
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1513802

A case of transcatheter aortic valve replacement in a patient with a small aortic annulus using the Acurate Neo2

Provisionally accepted
Shahzil Abdur Rehman Malik Shahzil Abdur Rehman Malik Jamshed Ali Jamshed Ali *Maleeha Javed Maleeha Javed *Kamran Hussain Kamran Hussain *Navaira Azeem Navaira Azeem Nasir Rehman Nasir Rehman *Osman Faheem Osman Faheem *
  • Aga Khan University, Karachi, Pakistan

The final, formatted version of the article will be published soon.

    Small aortic annulus poses a major challenge in aortic valve replacement due to the increased risk of prosthesis-patient mismatch (PPM) and increased surgical risk. In recent years, transcatheter aortic valve replacement (TAVR) has emerged as a popular alternative to the traditional surgical aortic valve replacement. We present the case of an 80-year-old female with a small aortic annulus who underwent TAVR using a self-expanding transcatheter heart valve Acurate Neo2, following an NSTEMI presentation. These risks, combined with advanced age, significant comorbidities, and a severely calcified small aortic annulus, supported the choice of TAVR with a self-expanding Acurate Neo2 valve. Despite multiple risk factors for PPM, the patient had a successful outcome without major complications. Our case highlights the off-label use of the Acurate Neo2 valve in one of the smallest aortic annuli reported to date, showcasing its feasibility in Asian and resource-limited settings.

    Keywords: Self-expanding transcatheter heart valves, Prosthesis-patient mismatch, Small aortic annulus, Resource limited settings, case report

    Received: 19 Oct 2024; Accepted: 15 Jan 2025.

    Copyright: © 2025 Malik, Ali, Javed, Hussain, Azeem, Rehman and Faheem. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jamshed Ali, Aga Khan University, Karachi, Pakistan
    Maleeha Javed, Aga Khan University, Karachi, Pakistan
    Kamran Hussain, Aga Khan University, Karachi, Pakistan
    Nasir Rehman, Aga Khan University, Karachi, Pakistan
    Osman Faheem, Aga Khan University, Karachi, Pakistan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.