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ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1512619
This article is part of the Research Topic Immune Cell Dynamics and Biomarkers in Cardiac Surgery-Induced Systemic Inflammatory Response View all 3 articles
The effect of HA380 blood adsorption on patients with acute infective endocarditis undergoing cardiac surgery: A retrospective study
Provisionally accepted
Jiefei Xiao 1,2
Han Shi 1,2 Yongxu Shi 1,2 Lu Cao 1,2 Shaoyan Mo 1,2 Yumei Jiang 1,2 Yonghua Li 1,2 Kai Qin 1,2 Yanling Zhu 1,2
Jian Rong 1,2*- 1 Department of Extracorporeal Circulation, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
- 2 Key Laboratory of Assisted Circulation, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China
Sepsis is a major cause of ICU admission and mortality in patients with infective endocarditis patients. This study aimed to explore the effect of intraoperative HA380 blood adsorption on surgical outcomes in infective endocarditis patients, given its ability to adsorb inflammatory factors.We retrospectively analyzed the clinical data of patients who underwent surgical treatment for infective endocarditis at our hospital. After propensity score matching, eligible patients were matched in a 1:1 ratio between HA380 users and non-users. The primary endpoint was the incidence of postoperative sepsis, while secondary outcomes included ICU stay , postoperative hospital stay, and the need for CRRT, IABP, and ECMO therapies. Laboratory results were compared at 24, 48, and 72 hours postoperatively.A total of 148 patients were included in the analysis. After 1:1 matching, 39 pairs were further analyzed. There was no significant difference in the incidence of postoperative sepsis (20.5% vs 15.4%, p=0.724). However, HA380 patients had a significantly shorter postoperative hospital stay (21.2 vs. 28.1 days, p=0.014), with no differences observed in the use of CRRT, IABP, or ECMO. Laboratory results showed that HA380 patients had significantly lower fibrinogen levels and a higher albumin-to-fibrinogen ratio.This study did not demonstrate a reduced risk of postoperative sepsis with HA380 blood adsorption. Although the HA380 group had a shorter postoperative hospital stay, lower fibrinogen levels, and a higher albumin-to-fibrinogen ratio, the overall effectiveness of HA380 requires further investigation.
Keywords: Infective endocarditis, HA380, Blood adsorption, Postoperative sepsis, Cardiopulmonary Bypass
Received: 17 Oct 2024; Accepted: 21 Feb 2025.
Copyright: © 2025 Xiao, Shi, Shi, Cao, Mo, Jiang, Li, Qin, Zhu and Rong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jian Rong, Department of Extracorporeal Circulation, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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