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SYSTEMATIC REVIEW article
Front. Cardiovasc. Med.
Sec. Atherosclerosis and Vascular Medicine
Volume 12 - 2025 |
doi: 10.3389/fcvm.2025.1511747
This article is part of the Research Topic Immunity, Atherosclerosis and Cardiovascular Disease: An Interdisciplinary Approach to Cardiometabolic Health View all 6 articles
Effects of sodium tanshinone IIA sulfonate injection on proinflammatory cytokines, adhesion molecules and chemokines in Chinese patients with atherosclerosis and atherosclerotic cardiovascular disease: a meta-analysis of randomized controlled trials
Provisionally accepted- China Pharmaceutical University, Nanjing, Jiangsu Province, China
Background: Inflammation, as the basic pathogenic mechanism of atherosclerosis, promotes the development of atherosclerosis (AS) and atherosclerotic cardiovascular disease (ASCVD). In numerous experiments based on animal and cellular models, sodium tanshinone IIA sulfonate (STS) injection has been found to reduce the levels of pro-inflammatory cytokines, adhesion molecules, and chemokines in patients with AS and ASCVD, exerting an anti-inflammatory effect to treat the disease.Objectives: This study aimed to perform a meta-analysis of randomized controlled trials (RCTs) to quantify the effects of STS on pro-inflammatory cytokines, adhesion molecules, and chemokines in patients with AS and ASCVD.Methods: Eight literature databases were searched from inception to
Keywords: Sodium tanshinone IIA sulfonate, Atherosclerosis, Arteriosclerotic cardiovascular disease, Meta-analysis, cardiovascular
Received: 15 Oct 2024; Accepted: 03 Feb 2025.
Copyright: © 2025 Xie, Fu, Li, Bao, Chang, Lu and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuqiong Lu, China Pharmaceutical University, Nanjing, 210009, Jiangsu Province, China
Yun Lu, China Pharmaceutical University, Nanjing, 210009, Jiangsu Province, China
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