94% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1493635
Correlation Between Stress Hyperglycemia Ratio and Prognosis in Acute Myocardial Infarction Patients Following Percutaneous Coronary Intervention
Provisionally accepted- Beijing Friendship Hospital, Capital Medical University, Beijing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Stress hyperglycemia ratio (SHR) is a commonly used predictor of acute hyperglycemia. The present study aimed to evaluate the prognostic significance of SHR in acute myocardial infarction (AMI) patients who underwent percutaneous coronary intervention (PCI).Methods: A total of 3,212 consecutive AMI patients who underwent PCI were recruited and assigned to three groups, according to SHR tertiles. Then, the total number of major adverse cardiovascular and cerebrovascular events (MACCEs) and various cardiovascular events were recorded. The SHR was determined, as follows: admission blood glucose (mmol/L) / (1.59 × hemoglobin A1c [%] -2.59).Results: The incidence of MACCEs was positively correlated to SHR during the median follow-up of 36 months. The multivariate COX regression analysis identified SHR as an independent predictor of composite MACCEs (hazard ratio: 2.279, 95% confidence interval [CI]: 1.569-3.311, p<0.001) and target vessel revascularization (hazard ratio: 1.998, 95% CI: 1.299-3.074, p=0.002). In terms of gender, age, type of AMI, body mass index, left ventricular ejection fraction, and diabetes mellitus, SHR >1.45 was significantly associated to MACCEs across all subgroups (all, p<0.001), except for patients with ejection fraction <50%. Furthermore, the area under the receiver operating characteristic curve for SHR in predicting MACCEs was 0.636 (95% CI: 0.613-0.659, p<0.05), with a cut-off value of 1.317.Conclusions: Stress hyperglycemia, as indicated by SHR, is significantly correlated to MACCEs, and independently predicts the prognosis of AMI patients undergoing PCI. These findings highlight the potential of SHR as an effective prognostic marker for AMI patients undergoing PCI.
Keywords: acute myocardial infarction, Major adverse cardiovascular and cerebrovascular events, Percutaneous Coronary Intervention, stress hyperglycemia, Stress hyperglycemia ratio
Received: 09 Sep 2024; Accepted: 09 Apr 2025.
Copyright: © 2025 Meng, Qiu, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hongwei Li, Beijing Friendship Hospital, Capital Medical University, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.